endocrine disorders
metabolic disorders
Endocrine Disorders
Endocrine disorders are rooted in an inability to sense a given signal and release required hormones in response. For example, someone with type 1 diabetes is unable to appropriately sense glucose and release insulin. Standard treatments requiring frequent monitoring, insulin delivery, and lifelong vigilance exact a tremendous toll on patients, their families, and society.
We are focused on developing bioprinted tissue therapeutics to transform the lives of people living with diseases like type 1 diabetes and rare endocrine disorders.
A Solution for
Type 1 Diabetes
By bioprinting allogeneic cells encapsulated within immune-protective materials, we are creating functional and retrievable pancreatic tissues. These tissues are surgically implanted into the body to maintain normal glycemia without the need for immune suppression. This therapeutic would represent a transformative cure for patients dependent on insulin injections.
Therapeutic cell: Stem cell islet clusters
Potential indication: Type 1 diabetes, type 2 diabetes, obesity
Stage of development: Pre-clinical
*Partnered program with Novo Nordisk*
Metabolic Disorders
Metabolic disorders affect the body’s ability to process and metabolize nutrients. Liver-related metabolic disorders can be genetic or acquired and can cause serious damage or even failure. Liver diseases and liver failure are becoming increasingly prevalent and patients have limited options. There is a shortage of suitable liver donors and liver transplant recipients require life-long immunosuppression.
We are developing a liver therapeutic platform to address an array of acquired and genetic liver-related conditions.
A Solution for
Liver Diseases
We are developing first-in-class allogeneic bioprinted cell therapies to restore lost or damaged liver function. These liver therapeutics would represent a breakthrough for patients suffering from acquired or genetic liver diseases.
Therapeutic Cell: Human hepatocytes
Indication: Acute liver failure, acute-on-chronic liver failure, liver-related genetic disorders
Stage of development: Pre-clinical
WHAT ARE BIOPRINTED TISSUE THERAPEUTICS?
- materials science
- cell biology
- 3D printing
- computer vision
We are pioneering the development of bioprinted tissue therapeutics to replace, repair, or supplement biological functions inside the body.
These implantable, allogeneic, cell-based therapies represent a paradigm shift in the traditional approach to regenerative medicine.
They can take on different forms — including retrievable implants or integrated tissues — to perform a variety of functions — including metabolic response, delivery of biologically active factors, or regeneration of damaged tissues.