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Guided Kidney Tissue Regeneration

Immuno-Oncology Model

Target Application

Guided Kidney Tissue Regeneration

End-stage kidney disease leads to significant reduction in quality of life, and high rates of mortality. JSR Corporation, a leading materials supplier in a variety of technology driven markets, and Aspect Biosystems are partnering to develop an implantable vascularized tissue for kidney regeneration and other applications in regenerative medicine. These studies focus on the development and validation of a bioprinted pre-vascularized 3D tissue implant for kidney regeneration, and will lay the foundation for long-term implantation of functional tissue therapeutics for the treatment of multiple chronic diseases.

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Target Application

Immuno-oncology

Solid tumour growth is highly regulated by cellular interactions within the tumour microenvironment (TME). Specifically, the interplay between tumour cells and associated stroma and immune cells within the TME represent a powerful relationship that influences disease initiation, progression, and patient prognosis. In collaboration with Merck, GSK, and Aspect Biosystems, Morag Park and her team at the Goodman Cancer Research Centre and McGill University Health Centre are leveraging the RX1™ Bioprinter and their biobank of patient-matched tumour-associated cells to develop a highly physiological, high-throughput tissue model that will enable the elucidation of mechanisms of the TME and ultimately lead to the development of an immuno-oncology model for the accurate and predictive screening of immuno-therapeutics targeting cancers, such as triple negative breast cancer.

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